Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

► Exosomes released from cells contain α-synuclein. ► Exosomes transfer α-synuclein protein between cells. ► Lysosomal defects seen in Parkinson's disease increase exosomal α-synuclein release. ► Lysosomal dysfunction increases α-synuclein transfer mediate by exosomes.