Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis

► TRPV1 channels are involved in a variety of inflammatory conditions. ► Genetic deletion of TRPV1 channels affected the clinical course of EAE. ► Ablation of TRPV1 channels exacerbated the effects of TNF-α on glutamate synapses. ► On the contrary, ablation of TRPV1 channels attenuated the synaptic action of IL-1β.