Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease

► Mammalian Atg8 homologues containing LC3 and GABARAPs are involved in autophagosomal formation. ► We examined whether Atg8 homologues were altered in Lewy body disease. ► All Atg8 homologues were localized in Lewy bodies. ► LC3 was the most vulnerable protein among them. ► Autophagic function can be impaired through alteration of Atg8 homologues in Lewy body disease.