کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6022922 1580703 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: A pathogenetically based approach
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: A pathogenetically based approach
چکیده انگلیسی
The inaccuracy of the early diagnosis of Parkinson's disease (PD) has been a major incentive for studies aimed at the identification of biomarkers. Brain-derived cerebrospinal fluid (CSF) proteins are potential biomarkers considering the major role that proteins play in PD pathogenesis. In this review, we discuss the current hypotheses about the pathogenesis of PD and identify the most promising candidate biomarkers among the CSF proteins studied so far. The list of potential markers includes proteins involved in various pathogenetic processes, such as oxidative stress and protein aggregation. This list will undoubtedly grow in the near future by application of CSF proteomics and subsequent validation of identified proteins. Probably a single biomarker will not suffice to reach high sensitivity and specificity, because PD is pathogenetically heterogeneous and shares etiological factors with other neurodegenerative diseases. Furthermore, identified candidate biomarkers will have to be thoroughly validated before they can be implemented as diagnostic aids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 39, Issue 3, September 2010, Pages 229-241
نویسندگان
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