کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6027963 | 1580918 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Visualization of mouse barrel cortex using ex-vivo track density imaging
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کلمات کلیدی
DTIFODTDIDWIDECCSDPMBSFVPMSpherical harmonics - هماهنگ های کروی، هارموینک های کرویConstrained spherical deconvolution - اختلاط کروی محدود شده استtrack density imaging - تراکم تصویر برداریMagnetic resonance - تشدید مغناطیسیDiffusion weighted imaging - تصویر برداری با وزن مخصوصtrack-density imaging - تصویربرداری با تراکم پیوستهdiffusion-weighted imaging - تصویربرداری با وضوح تصویربرداریdiffusion tensor imaging - تصویربرداری تانسور انتشارFiber orientation distribution - توزیع جهت گیری فیبرBarrel cortex - قشر بشکهMouse brain - مغز ماوسfractional anisotropy - ناپیوستگی کسریHARDI - هاردیVentral posteromedial thalamic nucleus - هسته تالاموم پس از معده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Visualization of mouse barrel cortex using ex-vivo track density imaging Visualization of mouse barrel cortex using ex-vivo track density imaging](/preview/png/6027963.png)
چکیده انگلیسی
We describe the visualization of the barrel cortex of the primary somatosensory area (S1) of ex vivo adult mouse brain with short-tracks track density imaging (stTDI). stTDI produced much higher definition of barrel structures than conventional fractional anisotropy (FA), directionally-encoded color FA maps, spin-echo T1- and T2-weighted imaging and gradient echo T1/T2*-weighted imaging. 3D high angular resolution diffusion imaging (HARDI) data were acquired at 48Â micron isotropic resolution for a (3Â mm)3 block of cortex containing the barrel field and reconstructed using stTDI at 10Â micron isotropic resolution. HARDI data were also acquired at 100Â micron isotropic resolution to image the whole brain and reconstructed using stTDI at 20Â micron isotropic resolution. The 10Â micron resolution stTDI maps showed exceptionally clear delineation of barrel structures. Individual barrels could also be distinguished in the 20Â micron stTDI maps but the septa separating the individual barrels appeared thicker compared to the 10Â micron maps, indicating that the ability of stTDI to produce high quality structural delineation is dependent upon acquisition resolution. Close homology was observed between the barrel structure delineated using stTDI and reconstructed histological data from the same samples. stTDI also detects barrel deletions in the posterior medial barrel sub-field in mice with infraorbital nerve cuts. The results demonstrate that stTDI is a novel imaging technique that enables three-dimensional characterization of complex structures such as the barrels in S1 and provides an important complementary non-invasive imaging tool for studying synaptic connectivity, development and plasticity of the sensory system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 87, 15 February 2014, Pages 465-475
Journal: NeuroImage - Volume 87, 15 February 2014, Pages 465-475
نویسندگان
Nyoman D. Kurniawan, Kay L. Richards, Zhengyi Yang, David She, Jeremy F.P. Ullmann, Randal X. Moldrich, Sha Liu, Javier Urriola Yaksic, Gayeshika Leanage, Irina Kharatishvili, Verena Wimmer, Fernando Calamante, Graham J. Galloway, Steven Petrou,