Multifaceted genomic risk for brain function in schizophrenia

► We analyze SNP data in conjunction with fMRI data using a multivariate approach. ► We identify a SNP component related to brain function disruptions in schizophrenia. ► Schizophrenia patients show disrupted functions in precentral and postcentral gyri. ► The related SNP component presents a combined effect from multiple SNPs and genes. ► The related SNP component involves four neurotransmitter signaling pathways.