The spatial distribution of age-related white matter changes as a function of vascular risk factors-Results from the LADIS study

► White matter changes are a frequent finding on brain MRI of elderly subjects. ► Overall severity is known to be associated with vascular risk factors. ► The spatial distribution of risk factor impact not well described. ► We apply voxel-based logistic regression to a large group of non-demented elderly. ► Particularly strong associations were found for age, gender and hypertension.