High b-value and diffusion tensor imaging in a canine model of dysmyelination and brain maturation

► A large animal model (shaking pups) of brain dysmyelination was studied. ► High b-value diffusion-weighted imaging and diffusion tensor imaging were used. ► Brain dysmyelination caused a decreased zero-displacement probability (Po). ► Brain dysmyelination caused an increased radial diffusivity of DTI. ► Control dogs had significant changes of diffusion measures as brain maturating.