کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6034544 | 1188755 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease](/preview/png/6034544.png)
چکیده انگلیسی
⺠Brain metal content is a potential target for early diagnosis and treatment of AD. ⺠In the PSAPP mouse, iron was elevated in the cortex at the onset of plaque formation. ⺠The elevated iron was not associated with the amyloid plaques. ⺠Iron, copper, and zinc were not elevated in PSAPP plaques at time points up to 56 weeks. ⺠Only the zinc content was elevated at 56 weeks, representing a marker of late-stage AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 55, Issue 1, 1 March 2011, Pages 32-38
Journal: NeuroImage - Volume 55, Issue 1, 1 March 2011, Pages 32-38
نویسندگان
Andreana C. Leskovjan, Ariane Kretlow, Antonio Lanzirotti, Raul Barrea, Stefan Vogt, Lisa M. Miller,