کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6036342 1188775 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β-Amyloid affects frontal and posterior brain networks in normal aging
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
β-Amyloid affects frontal and posterior brain networks in normal aging
چکیده انگلیسی

Although deposition of β-amyloid (Aβ), a pathological hallmark of Alzheimer's disease (AD), has also been reported in cognitively intact older people, its influence on brain structure and cognition during normal aging remains controversial. Using PET imaging with the radiotracer Pittsburgh compound B (PIB), structural MRI, and cognitive measures, we examined the relationships between Aβ deposition, gray matter volume, and cognition in older people without AD. Fifty-two healthy older participants underwent PIB-PET and structural MRI scanning and detailed neuropsychological tests. Results from the whole-brain voxel-based morphometry (VBM) analysis revealed that gray matter volume in the left inferior frontal cortex was negatively associated with amyloid deposition across all participants whereas reduced gray matter volume was shown in the posterior cingulate among older people with high amyloid deposition. When gray matter density measures extracted from these two regions were related to other brain regions by applying a structural covariance analysis, distinctive frontal and posterior brain networks were seen. Gray matter volume in these networks in relation to cognition, however, differed such that reduced frontal network gray matter volume was associated with poorer working memory performance while no relationship was found for the posterior network. The present findings highlight structural and cognitive changes in association with the level of Aβ deposition in cognitively intact normal elderly and suggest a differential role of Aβ-dependent gray matter loss in the frontal and posterior networks in cognition during normal aging.

Research highlights►Aβ deposition relates to gray matter volume reduction in the lIFG and PCC. ►Structural covariance patterns with lIFG reveal the frontal network. ►Structural covariance patterns with PCC reveal the posterior network. ►Effects of frontal and posterior networks on cognition differ in normal aging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 54, Issue 3, 1 February 2011, Pages 1887-1895
نویسندگان
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