کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
605328 880343 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of carboxymethyl chitosan hydrogel beads in alcohol-aqueous binary solvent for nutrient delivery applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Development of carboxymethyl chitosan hydrogel beads in alcohol-aqueous binary solvent for nutrient delivery applications
چکیده انگلیسی

Carboxymethyl chitosan (CMCS) hydrogel beads were normally prepared from a composite formulation with other polymers, such as alginate. In present study, a novel method was developed to prepare CMCS hydrogel beads in alcohol-aqueous binary solvents. The morphology and shape of the beads were highly dependent on alcohol concentration. The most spherical hydrogel beads were obtained with 3% calcium and 30% alcohol concentration. The chemical crosslinking agent, glutaraldehyde, was needed to maintain the hydrogel integrity and morphology upon drying. Vitamin D3, a model nutrient, was encapsulated into the beads and 96.9% encapsulation efficiency was obtained. The effects of freeze-drying and room temperature drying were studied on the swelling behaviors and release properties in simulated gastrointestinal conditions. Possible mechanisms for CMCS hydrogel beads formation in binary solvents were discussed. The CMCS hydrogel beads prepared in 30% alcohol-aqueous binary solvent may be a promising delivery system for hydrophobic nutrients or drugs.

Figure optionsDownload as PowerPoint slideHighlights
► Carboxymethyl chitosan (CMCS) hydrogel beads were prepared in 30% alcohol-aqueous solution.
► Chemical crosslinking was needed to maintain the integrity of CMCS hydrogel beads.
► Different drying methods resulted in different morphology of CMCS hydrogel beads.
► CMCS beads possessed high potential for encapsulation and drug delivery applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Hydrocolloids - Volume 31, Issue 2, June 2013, Pages 332–339
نویسندگان
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