کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6054894 1198758 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Narrow band imaging in the intra-operative definition of resection margins in oral cavity and oropharyngeal cancer
ترجمه فارسی عنوان
تصویربرداری باند باریک در تعریف درونی عملیات حاشیه برداشت در حفره دهان و سرطان رحم
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


- We propose a new surgical approach to reduce positive margins at histological examination.
- We compare the resection margins defined with white light and narrow band imaging.
- All margins were negative for dysplasia or cancer at extemporaneous histology.
- One patient had a margin positive for cancer and one for moderate dysplasia at definitive histology.
- 25% of NBI-defined enlargements were positive for dysplasia and 75% for cancer.

SummaryObjectivesIn oncological surgery, a three-dimensional resection 1.5-2 cm from the gross tumour edge is currently considered appropriate, and the status of resection margins is the most reliable indicator of radicality. Awareness of “field cancerization” calls for a re-evaluation of the benchmarks of tumour resection; however, its identification is not simple because the dysplastic areas may be far from the main lesion and difficult to recognize macroscopically. New technologies such as narrow band imaging (NBI) could improve the detection of neoplastic and pre-neoplastic areas, ensuring more precise resections. The main purpose of this study was to investigate the value of NBI in detecting pre-cancerous areas and/or cancer around the tumour bulk intra-operatively, to achieve adequate resection of the tumour.Materials and MethodsThe resection margins of 8 oral cavity and 8 oropharyngeal cancers were first drawn by macroscopic evaluation and then re-defined using NBI. Resections were performed following the NBI-drawing if extemporaneous histological examinations of the NBI-defined enlargements were positive for dysplasia or cancer. The number of clear margins was evaluated.ResultsResections margins were free of tumour or dysplasia at extemporaneous examination; on definitive histology, two patients had a margin positive for cancer and dysplasia, respectively. Among the NBI-defined enlargements, 25% were positive for dysplasia and 75% for cancer. The sensitivity, specificity, positive and negative predictive values were 100%, 88.9%, 100% and 87.5%, respectively.ConclusionThe method we propose could be useful for obtaining free surgical margins and reducing the potential development of tumour foci resulting from incomplete resection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 51, Issue 10, October 2015, Pages 908-913
نویسندگان
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