کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6055390 | 1198806 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A randomized controlled trial of visible-light therapy for the prevention of oral mucositis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The objective of this study was to assess the efficacy of a novel visible-light therapy (VLT) device for the prevention of oral mucositis in hematopoietic stem cell transplantation (HSCT) patients. A VLT-device suitable for intra-oral use was applied to 20 patients undergoing HSCT. The study design was placebo-controlled, randomized and double-blind. Oral mucositis was assessed using the OMAS and WHO scales. Oral pain and acceptance levels were scored by the patient using a 10-step scale. Patients were evaluated once a week until day 21 post-HSCT. Mucositis rate, severity and pain score were compared. At the third visit, 1 week post-HSCT, mucositis rates were significantly lower in the treatment group (for both WHO and OMAS p = 0.02). Mucositis was also less severe in the treatment group (for WHO p = 0.01; for OMAS p = 0.01). Furthermore, the patients in the treatment group reported lower pain levels (p = 0.04). The treatment was well tolerated and highly accepted, with no reports of adverse events related to the device. These findings suggest that the VLT-device is safe and effective for the prevention of oral mucositis in patients undergoing HSCT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 47, Issue 2, February 2011, Pages 125-130
Journal: Oral Oncology - Volume 47, Issue 2, February 2011, Pages 125-130
نویسندگان
Sharon Elad, Noa Luboshitz-Shon, Tehila Cohen, Elad Wainchwaig, Michael Y. Shapira, Igor B. Resnick, Ruth Radiano, Rachel Lubart, Reuven Or,