Genetic variants associated with sleep disorders

- Patients undergoing polysomnography consented to research use of clinical data.
- DNA was genotyped from saliva samples.
- Peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B) rs6888451 was associated with several markers of obstructive apnea.
- Aryl hydrocarbon receptor nuclear translocator-like (ARNTL) rs10766071 was associated with decreased polysomnographic sleep duration.
- BTBD9 rs3823798 was associated with periodic limb movements but not restless legs.