کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6060487 1200230 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review ArticleEarly-life origin of adult insomnia: does prenatal-early-life stress play a role?
ترجمه فارسی عنوان
بررسی وضعیت بی خوابی بزرگسالان: آیا استرس قبل از زایمان و زودرس نقش مهمی دارد؟
کلمات کلیدی
قبل از تولد، دوران کودکی، فشار، اپی ژنتیک، بی خوابی بزرگسالان،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Prenatal-early-life stress may result in an activation of the stress system in the newborn.
- It may encompass long-lasting modifications in stress reactivity, which may persist into adulthood.
- It might predispose to a vulnerability to stress-related hyperarousal and insomnia into adulthood.
- Epigenetic mechanisms may be involved in shaping stress responses predisposing to insomnia.

Insomnia is very common in the adult population and it includes a wide spectrum of sequelae, that is, neuroendocrine and cardiovascular alterations as well as psychiatric and neurodegenerative disorders. According to the conceptualization of insomnia in the context of the 3-P model, the importance of predisposing, precipitating, and perpetuating factors has been stressed. Predisposing factors are present before insomnia is manifested and they are hypothesized to interact with precipitating factors, such as environmental stressful events, contributing to the onset of insomnia. Understanding the early-life origins of insomnia may be particularly useful in order to prevent and treat this costly phenomenon. Based on recent evidence, prenatal-early-life stress exposure results in a series of responses that involve the stress system in the child and could persist into adulthood. This may encompass an activation of the hypothalamic-pituitary-adrenal axis accompanied by long-lasting modifications in stress reactivity. Furthermore, early-life stress exposure might play an important role in predisposing to a vulnerability to hyperarousal reactions to negative life events in the adult contributing to the development of chronic insomnia. Epigenetic mechanisms may also be involved in the development of maladaptive stress responses in the newborn, ultimately predisposing to develop a variety of (psycho-) pathological states in adult life.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sleep Medicine - Volume 16, Issue 4, April 2015, Pages 446-456
نویسندگان
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