کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6060564 | 1200233 | 2014 | 5 صفحه PDF | دانلود رایگان |
BackgroundIncreased left atrial (LA) size is linked to elevated mortality in end-stage renal disease (ESRD). In addition, the degree of overnight rostral fluid shift from the legs is associated with severity of obstructive sleep apnea (OSA). As rostral fluid shift might distend the left atrium and increase fluid accumulation in the neck, we postulated that LA size would be related to the degree of overnight rostral fluid shift and OSA severity in ESRD patients.MethodsPatients with ESRD underwent echocardiography and polysomnography. Leg fluid volume (LFV) was measured by bioelectrical impedance before and after the overnight sleep study in a subset of 21 patients.ResultsForty patients (22 men), with a mean apnea-hypopnea index (AHI) of 25.1â±â23.4/h of sleep, had echocardiography and polysomnography performed. In men, there was a correlation between the AHI and LA size indexed for body surface area (râ=â0.743, pâ<â0.001) that was not observed in women. Strong relationships were seen, again in men only, between LA size indexed to body surface area and the overnight change in leg fluid volume (ÎLFV) (râ=ââ0.739, pâ=â0.02) and between AHI and ÎLFV (râ=ââ0.863, pâ=â0.003).ConclusionsIn ESRD patients, there are relationships between ÎLFV and both LA size and OSA severity. These findings suggest that the relationship between LA size and mortality in ESRD may be related to ÎLFV and severity of OSA.
Journal: Sleep Medicine - Volume 15, Issue 11, November 2014, Pages 1314-1318