کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6086350 | 1207177 | 2014 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exploring & exploiting our 'other self' - Does the microbiota hold the key to the future therapy in Crohn's?
ترجمه فارسی عنوان
کاوش و بهره برداری از "دیگر خود" ما - آیا میکروبوتا کلیدی برای درمان آینده در کرون است؟
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کلمات کلیدی
بیماری کرون، بیماری روده التهابی میکروبیوتا، پروبیوتیک ها، پیش داروئی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی
Inflammatory bowel diseases (IBD) with its two major forms Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing disorders leading to inflammation of the gastrointestinal tract. Although the precise aetiology of IBD remains unclear, several factors are believed to contribute to disease pathogenesis. Among these, the role of the intestinal microbiota has become more and more appreciated. Evidence from experimental and clinical studies strongly suggests that chronic intestinal inflammation results from a dysregulated immune response towards components of the microbiota in genetically susceptible hosts. The growing perception of the microbiota as a major driver of disease pathogenesis raises the question, if the intestinal microbiota can be used as a therapeutic target in CD. Based on what we know about host microbiota interactions in health and disease, the objective of this review is to address the question if the microbiota holds the key to the future therapy in CD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Gastroenterology - Volume 28, Issue 3, June 2014, Pages 399-409
Journal: Best Practice & Research Clinical Gastroenterology - Volume 28, Issue 3, June 2014, Pages 399-409
نویسندگان
Lea-Maxie (Resident), Britta (Head of Department),