کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087072 1589423 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation
چکیده انگلیسی


- 1,25(OH)2D3 and 25(OH)D3 both decreased the secretion of pro-inflammatory cytokines
- Vitamin D metabolites increase IL-10 secretion in Th17 cells
- Vitamin D reduced the frequency of Th17 cells expressing pathogenic markers
- 1,25(OH)2D3 and 25(OH)D3 induced CD25hiFoxp3+ CTLA4+ expression
- VDR expression is induced in Th17 cells after treatment with both forms of vitamin D

Vitamin D is a secosteroid hormone that plays an important regulatory role in calcium homeostasis and bone metabolism. Immune cells can both produce and respond to 1,25(OH)2D3. CD4 + T cells from vitamin D receptor (VDR) KO mice produce higher levels of IFN-γ and IL-17 than their wild type counterparts, and play a crucial role in the pathogenesis of autoimmune diseases (AID). We are particularly interested in studying the effect of vitamin D on pathogenic Th17 cells in humans.We investigated the in vitro effect of 1,25(OH)2D3 and 25(OH)D3 on the differentiation and cytokine production of primary CD4 + T cells from normal donors, and cultured in Th17 polarizing conditions. Both forms of vitamin D reduced the expression of pathogenic Th17 markers and their secretion of pro-inflammatory cytokines (IL-17A, IFN-γ). Furthermore, both vitamin D forms induced an expansion of CD25hi cells and upregulated their expression of CTLA-4 and Foxp3 regulatory markers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volumes 166–167, May 2016, Pages 59-71
نویسندگان
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