کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087099 1207349 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus
ترجمه فارسی عنوان
ترکیبات ژنتیکی پلی مورفیسم مرتبط با لپتین با لوپوس اریتماتیک سیستمیک
کلمات کلیدی
لوپوس اریتماتوی سیستمیک، مسیر لپتین، پلی مورفیسم ژن،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- 15,706 individuals of four difference ancestral groups were genotyped for polymorphisms in four genes related to the leptin pathway for possible association with SLE.
- Several SNPs showed weak associations that did not remain significant after correction for multiple testing.
- None of the tested leptin-related polymorphisms associated with increased risk for SLE.

Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 161, Issue 2, December 2015, Pages 157-162
نویسندگان
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