کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087149 1207349 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemokine receptor expression on monocytes from healthy individuals
ترجمه فارسی عنوان
بیان گیرنده کیموکین در مونوسیت ها از افراد سالم
کلمات کلیدی
گیرنده کیموکین، مونوسیتها، ایمنی عامل بیماری، مقادیر مرجع،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- Normal reference values established for 20 chemokine receptors on monocytes
- Global evaluation of classical, non-classical and HLA-DRhi monocyte subsets
- Monocyte subsets display unique migration profiles in chemokine receptor expression.

Chronic immune mediated inflammation is characterized by continuous chemokine mediated recruitment and activation of pro-inflammatory cells, monocytes in particular. We believe that an evaluation of the recruitment profile of monocytes during healthy condition is essential for the understanding of cellular response in disease. For this, we have established normal reference values and 95% confidence intervals for receptor expression of 20 chemokine receptors on monocyte subsets; classical (CD14+ CD16−), non-classical (CD14+ CD16+) and HLA-DRhi monocytes from 20 healthy controls using flow cytometry. We demonstrate significant differences in the chemokine receptor expression profiles and high correlation between fraction of cells and level of expression. This is the first global approach to provide a platform for comparable evaluation of cell recruitment during normal and under inflammatory conditions. This will be useful when exploring chemokine-chemokine receptor interactions, inhibition of chemokine signaling and selective removal of migrating cells, which are new treatment strategies in immune mediated diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 161, Issue 2, December 2015, Pages 348-353
نویسندگان
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