کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6087549 | 1589429 | 2014 | 9 صفحه PDF | دانلود رایگان |

- Predictive value of eosinophil/basophil (Eo/B) progenitor numbers at birth was studied.
- Higher numbers of cord blood Eo/B progenitor cells predict respiratory outcomes later in life.
- Tobacco smoke related benzene exposure supports the activation of these progenitors.
- A Th2 immune status at birth further contributes to higher cord blood Eo/B numbers.
RationaleCord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment.MethodsIn a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation.ResultsCord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24Â months.ConclusionsThe association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.
Journal: Clinical Immunology - Volume 152, Issues 1â2, MayâJune 2014, Pages 68-76