کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087643 1207375 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2 + Tregs within the tumor microenvironment
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2 + Tregs within the tumor microenvironment
چکیده انگلیسی


- TNFR2 + Tregs are present at high levels within the ascites of ovarian cancer.
- Ascitic TNFR2 + Tregs are more suppressive compared to peripheral blood TNFR2 + Tregs.
- Ascitic TNFR2 + Tregs express high levels of multiple suppressive mediators.
- TNFR2 + Tregs are more capable of migrating into tumor ascites.
- TNFR2 + Tregs can dampen local IFNγ and IL2 production by effector T cells.

Ovarian cancer is a prevalent gynecological malignancy with potent immune-suppression capabilities; regulatory T cells (Tregs) are significant contributors to this immune-suppression. As ovarian cancer patients present with high levels of TNF and Tregs expressing TNFR2 are associated with maximal suppressive capacity, we investigated TNFR2 + Tregs within these patients. Indeed, TNFR2 + Tregs from tumor-associated ascites were the most potent suppressor T cell fraction. They were abundantly present within the ascites and more suppressive than peripheral blood TNFR2 + Tregs in patients. The increased suppressive capacity can be explained by a distinct cell surface expression profile, which includes high levels of CD39, CD73, TGF-β and GARP. Additionally, CD73 expression level on TNFR2 + Tregs was inversely correlated with IFN-γ production by effector T cells. This Treg fraction can be selectively recruited into the ascites from the peripheral blood of patients. Targeting TNFR2 + Tregs may offer new approaches to enhance the poor survival rates of ovarian cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 149, Issue 1, October 2013, Pages 97-110
نویسندگان
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