کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087736 1207382 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewReprint of: B cell elimination in systemic lupus erythematosus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
ReviewReprint of: B cell elimination in systemic lupus erythematosus
چکیده انگلیسی

Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution, potentially life-threatening with considerable morbidity. The elimination of pathogenic B cells has emerged as a rational therapeutic option. Many open label studies have reported encouraging results in which clinical and serological remission have invariably been described, often enabling the reduction of steroid and immunosuppressive treatment. However, the results from randomized controlled studies have been disappointing and several questions remain to be answered. In this review we will focus on results of B cell direct depletion in the treatment of patients with systemic lupus erythematosus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 148, Issue 3, September 2013, Pages 344-358
نویسندگان
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