کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6087763 1207398 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells
چکیده انگلیسی

Antimicrobial peptides are essential elements of epithelial defense against invading micro-organisms. The palatine tonsils are positioned at the entry of the airway and the gut and as such are ideally situated to act as immune sentinels in the pharynx protecting against microbial invasion. Tonsils express a number of antimicrobial peptides including hCAP18/LL-37. Here we clearly define the expression of hCAP18/LL-37 in the tonsils showing unequivocally that hCAP18/LL-37 is mainly expressed by infiltrating neutrophils and follicular CD11c+CD13+HLA-DR+ dendritic cells, rarely by macrophages, and never by the epithelium itself. To explore possible functions for follicle-derived LL-37, we stimulated tonsil mononuclear cells with LL-37 in vitro and observed the secretion of the proinflammatory cytokines CCL5 and CXCL9, expression of IFN-γ and MX-1 and down-regulation of chemokine receptors CCR4 and CCR6 which are involved in tissue-selective T cell trafficking. Taken together, these data illustrate new potential immunoregulatory functions for hCAP18/LL-37 in the tonsils.

► hCAP18/LL37 is an antimicrobial peptide (AMP) essential for epithelial defense. ► The palatine tonsils are immune sentinels in the pharynx and express AMPs. ► hCAP18/LL37 is strongly expressed in the tonsils by neutrophils, not epithelial cells. ► Follicular CD11c+CD13+ dendritic cells also express hCAP18/LL-37. ► Follicular hCAP18/LL-37 may modulate chemokine activity by tonsil immunocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 142, Issue 2, February 2012, Pages 139-149
نویسندگان
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