کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6089660 1208548 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Applied nutritional investigationImproved safety with intravenous insulin therapy for critically ill patients with renal failure
ترجمه فارسی عنوان
بررسی های تغذیه ای کاربردی بهبود ایمنی با تزریق انسولین درمانی برای بیماران مبتلا به نارسایی کلیوی
کلمات کلیدی
آسیب حاد کلیه، انسولین منظم انسانی، تغذیه انتالال، تغذیه تزریقی هیپوگلیسمی، هیپرگلیسمی، تروما بیماری مزمن کلیوی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

ObjectiveThe aim of this study was to evaluate the safety and efficacy of a new intravenous (IV) regular human insulin infusion (RHI) algorithm for glycemic control in critically ill patients with renal failure.MethodsAdult trauma patients with renal failure who received a new RHI algorithm were compared with those who received the discontinued RHI algorithm (historical control). Target blood glucose (BG) concentration was 70 to 149 mg/dL (3.9-8.3 mmol/L). Patients were evaluated for 7 d while receiving the RHI infusion and continuous enteral or parenteral nutrition.ResultsMean BG was higher for the new RHI algorithm group (n = 25) compared with control (n = 21): 145 ± 10 mg/dL or 8.1 ± 0.6 mmol/L versus 133 ± 14 mg/dL or 7.4 ± 0.8 mmol/L (P = 0.001). The new RHI algorithm resulted in less time within the target BG range (11.9 ± 2.5 h/d versus 16.1 ± 3.3 h/d; P = 0.001); however, BGs were within 70 to 179 mg/dL (or 3.9-10 mmol/L) for 16.3 ± 2.6 h/d. The proportion of patients who experienced an episode of moderate hypoglycemia (BG 40-60 mg/dL or 2.2-3.3 mmol/L) or severe hypoglycemia (BG < 40 mg/dL or 2.2 mmol/L) was decreased (32% versus 76%; P = 0.001) and eliminated (0% versus 29%, P = 0.006), respectively.ConclusionsThe new RHI algorithm improved patient safety by decreasing the prevalence of moderate hypoglycemia and eliminating severe hypoglycemia. The duration of glycemic control within the target BG range was decreased, but acceptable within a higher target BG ceiling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 30, Issue 5, May 2014, Pages 557-562
نویسندگان
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