کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6113660 1212349 2014 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From old alkylating agents to new minor groove binders
ترجمه فارسی عنوان
از عوامل آلکیل کننده قدیمی به گیرنده های کوچک جزئی کوچک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Alkylating agents represent the oldest class of anticancer agents with the approval of mechloretamine by the FDA in 1949. Even though their clinical use is far beyond the use of new targeted therapies, they still occupy a major place in the treatment of specific malignancies, sometimes representing the unique option for the treatment of refractory tumors. Here, we are reviewing the major classes of alkylating agents, with a particular focus on the latest generations of compounds that specifically target the minor groove of the DNA. These naturally occurring derivatives have a unique mechanism of action that explains the recent regain of interest in developing new classes of alkylating agents that could be used in combination with other anticancer drugs to enhance tumor response in the clinic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 89, Issue 1, January 2014, Pages 43-61
نویسندگان
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