کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6113973 | 1213513 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A randomized double blind control trial comparing filgrastim and pegfilgrastim in cyclophosphamide peripheral blood hematopoietic stem cell mobilization
ترجمه فارسی عنوان
یک کارآزمایی کنترل تصادفی دوسو کور در مقایسه با فیلگرواستیم و پگفیل گراستیم در بسیج سلول های بنیادی خون محیطی سیکلوفسفامید
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
چکیده انگلیسی
There are few randomized trials comparing filgrastim and pegfilgrastim in peripheral blood stem cell mobilization (PBSCM). None of the trials studied the effects of the timing of pegfilgrastim administration on the outcomes of mobilization. We conducted a randomized triple blind control trial comparing the outcomes of filgrastim 5âµg/kg daily from day 3 onwards, 'early' pegfilgrastim 6âmg on day 3 and 'delayed' pegfilgrastim 6âmg on day 7 in cyclophosphamide PBSCM in patients with no previous history of mobilization. Peripheral blood (PB) CD34+ cell count was checked on day 8 and day 11 onward. Apheresis was started when PB CD34+ââ¥â10/µl from day 11 onward. The primary outcome was the successful mobilization rate, defined as cumulative collection of â¥2âÃâ106/kg CD34+ cells in three or less apheresis. The secondary outcomes were the day of neutrophil and platelet engraftment post transplantation. There were 156 patients randomized and 134 patients' data analyzed. Pegfilgrastim 6âmg day 7 produced highest percentage of successful mobilization, 34 out of 48 (70.8%) analyzed patients, followed by daily filgrastim, 28 out of 44 (63.6%) and day 3 pegfilgrastim, 20 out of 42 (47.6%) (pâ=â0.075). Pegfilgrastim day 7 and daily filgrastim reported 1.48 (pâ=â0.014) and 1.49 (pâ=â0.013) times higher successful mobilization rate respectively as compared to pegfilgrastim day 3 after adjusting for disease, gender and exposure to myelotoxic agent. Multiple myeloma patients were three times more likely to achieve successful mobilization as compared to acute leukemia or lymphoma patients. Pegfilgrastim avoided the overshoot of white cells compared to filgrastim. There was no difference in the duration of both white cells and platelet recovery post transplantation between the three interventional arms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 53, Issue 2, October 2015, Pages 196-204
Journal: Transfusion and Apheresis Science - Volume 53, Issue 2, October 2015, Pages 196-204
نویسندگان
Jew-Win Kuan, Anselm-Ting Su, Shu-Ping Wong, Xavier Yoon-Han Sim, See-Guan Toh, Tee-Chuan Ong, Jay-Suria Rajasuriarr, Su-Hong Lim, Yong-Khee Guan, Hong-Keng Liew, Pek-Kuen Liew, Jerome Tsen-Chuen Tan, Ahlam-Naila Kori, Yuin-Yin Cheng, Sen-Mui Tan,