Val247Leu beta2-glycoprotein-I allelic variant is associated with antiphospholipid syndrome: Systematic review and meta-analysis

► The possession of the Val/Val genotype is associated with a higher risk of suffering from antiphospholipid syndrome. ► This genotype in antiphospholipid syndrome patients confers a higher risk of having anti-β2-glycoprotein I antibodies. ► These results emphasize the importance of this glycoprotein in the pathogenesis of this syndrome.