کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6114552 | 1214222 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Autoantibodies targeting the proliferating cell nuclear antigen (PCNA) were first described over 30Â years ago and are historically most commonly associated with systemic lupus erythematosus (SLE). The primary antigenic target is a 34Â kDa protein that is part of the DNA polymerase delta multi-protein complex. A number of diagnostic platforms have incorporated PCNA into their diagnostic assays and algorithms. However, little is known about the clinical utility of autoantibodies to PCNA, especially with novel detection systems. This review will focus on the history of the discovery of the PCNA autoantigen and the current status of the diagnostic significance of anti-PCNA and suggest future studies that are required to strengthen our understanding of their clinical utility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 11, Issue 10, August 2012, Pages 771-775
Journal: Autoimmunity Reviews - Volume 11, Issue 10, August 2012, Pages 771-775
نویسندگان
Michael Mahler, Kiyomitsu Miyachi, Carol Peebles, Marvin J. Fritzler,