Intravenous immunoglobulin for the treatment of Crohn's disease

► There is an urgent need for alternatives to anti-TNF drugs in Crohn's disease (CD). ► IVIG has been used in CD for years, although few data, and no RCTS, are published. ► A literature review shows that IVIG can induce rapid improvement in CD within days. ► Longer-term data show that maintenance of remission over the medium term is possible. ► Verification is needed from large RCTs to show the safety and efficacy of IVIG in CD.