کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6114666 1214241 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased risk of high grade cervical squamous intraepithelial lesions in systemic lupus erythematosus: A meta-analysis of the literature
ترجمه فارسی عنوان
افزایش خطر ابتلا به ضایعات داخلی داخل نخاعی شکمی گردن رحم در لوپوس اریتماتیک سیستمیک: یک متاآنالیز ادبیات
کلمات کلیدی
لوپوس اریتماتوی سیستمیک، ویروس پاپیلومای انسانی، ضایعه داخلی داخل اپیتلیال در رده بالا نئوپلاسی داخل رحم سرویکس، سرطان دهانه رحم، متاآنالیز،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Conflicting data have been published regarding the risk of cervical lesions among women with systemic lupus erythematosus (SLE). We systematically reviewed the evidence for an association of SLE with cervical precancerous lesions (high-grade squamous intraepithelial lesions, HSIL), and performed a meta-analysis to determine the risk of HSIL in SLE patients. Observational studies identified up to February 2013 from the Medline, Embase and Cochrane databases were selected if they assessed the prevalence of HSIL in female SLE patients versus healthy female controls and included in a meta-analysis with pooled effect estimates obtained using a random-effects model. Of 235 citations retrieved, 7 studies met inclusion criteria. The pooled odds ratio for the risk of HSIL in SLE patients (n = 416) versus female controls (n = 11,408) was 8.66 (95% CI: 3.75-20.00), without significant heterogeneity across studies. Cumulative meta-analysis according to year of study publication revealed a slight increase in the risk of HSIL in the 2001-2011 period and then a stabilization afterwards. This meta-analysis shows that the risk of HSIL is significantly increased in SLE patients, compared to healthy female controls. This suggests that women with SLE may benefit from HPV vaccines and specific cervical cancer screening.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 13, Issue 7, July 2014, Pages 730-735
نویسندگان
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