کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6122872 1592416 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lower response to early T-cell-dependent vaccination after neurotrauma or neurosurgery in adults
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Lower response to early T-cell-dependent vaccination after neurotrauma or neurosurgery in adults
چکیده انگلیسی


- Pneumococcal conjugate vaccine is recommended after neurotrauma.
- Central nervous system injury-induced immunodepression could affect the response.
- Patients were vaccinated within 10 days from trauma/surgery, controls after 3 weeks.
- Antibody concentration was lower in patients vaccinated within 10 days.
- Investigation of vaccine response in neurotrauma patients is therefore urgent.

SummaryBackgroundRecent international guidelines recommend vaccination with a 13-valent pneumococcal conjugate vaccine to reduce the risk of meningitis after neurotrauma with cerebrospinal fluid leak. The antibody response and optimal time point for vaccination have not been established and because the risk of meningitis is at the highest shortly after trauma, early vaccination is preferable. This study aimed to investigate the antibody response and to ensure that central nervous system injury-induced immunodepression did not affect the response to a T-cell-dependent conjugate vaccine when administered shortly after the injury.MethodsSo as not to interfere with routine pneumococcal vaccination, a conjugate vaccine against Haemophilus influenza type b (Hib) was chosen for the study. Thirty-three patients with basilar skull fracture and 23 patients undergoing transsphenoidal pituitary gland surgery were vaccinated within 10 days after trauma/surgery and 29 control patients at least three weeks after trauma/surgery. Sera were collected pre- and post-vaccination for analysis of anti-Hib concentration.ResultsFour patients with post-vaccination target antibody concentration before vaccination were excluded from analysis. In the neurotrauma and neurosurgery groups 10/32 (31%) and 5/20 (25%) patients, respectively, were non-responders compared with 3/29 (10%) in the control group. Log10 anti-Hib concentrations in the neurotrauma, neurosurgery and control groups were 1.52 ± 0.15, 1.38 ± 0.15 and 1.81 ± 0.12 μg/ml, respectively.ConclusionsThe majority of the patients responded to vaccination. However, the number of responders was significantly decreased and antibody concentration significantly lower in patients vaccinated early after the trauma/surgery. Investigation of the pneumococcal conjugate vaccine response in neurotrauma patients is therefore urgent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 70, Issue 6, June 2015, Pages 577-584
نویسندگان
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