Evaluation of circulating cathodic antigen (CCA) urine-cassette assay as a survey tool for Schistosoma mansoni in different transmission settings within Bugiri District, Uganda

We present an evaluation of two urine circulating cathodic antigen (CCA) cassette assays, one commercially available (CCA1 upper) and the other in experimental production (CCA2 lower) shown in the photograph below. The assays were evaluated against Kato-Katz test as a gold standard. Overall, the performance of the commercially available CCA1 test was more informative than by faecal smear microscopy, and is recommended as a satisfactory method for Schistosoma mansoni mapping and surveillance.