Colloidal, in vitro and in vivo anti-leishmanial properties of transfersomes containing paromomycin sulfate in susceptible BALB/c mice

► Topical paromomycin transfersomes cured L. major lesions on BALB/c mice. ► Topical paromomycin transfersomes decreased significantly the spleen parasite burden. ► Transfersomes increased significantly the paromomycin penetration through skin mice.