Assessment of drug resistance related genes as candidate markers for treatment outcome prediction of cutaneous leishmaniasis in Brazil

► Assessment of therapeutic outcome prediction for American cutaneous leishmaniasis. ► AQP1, MRPA, TRYR and hsp70 DNA sequencing allows L. (Viannia) species typing. ► L. braziliensis has higher intraspecific genetic variability than L. guyanensis. ► A to G change at position 1735 of hsp70 gene increased treatment failure chances. ► hsp70 of L. braziliensis showed the best treatment failure prediction model.