Molecular monitoring of antimalarial drug resistance among Plasmodium falciparum field isolates from Odisha, India

► Molecular monitoring of CQ and SP resistance markers reveals. ► The parasite populations of the state still have intrinsic resistant to CQ. ► High prevalence of SP resistant mutations with their observed non-random associations warns drug policy change in the combination therapy with ART. ► Strategic minimization of uneven drug pressure are needed to prevent and combat the drug resistance malaria.