Pharmacokinetics and in vivo chemosuppressive activity studies on cryptolepine hydrochloride and cryptolepine hydrochloride-loaded gelatine nanoformulation designed for parenteral administration for the treatment of malaria

- We designed gelatin nanoparticles for the antimalarial cryptolepine compound.
- We conducted pharmacokinetics studies for cryptolepine nanoparticles.
- The nanoparticles demonstrated higher AUC and lower rate of elimination in comparison to solution.
- Nanoparticles have improved cryptolepine chemosuppressive activity.