Monoclonal antibody 12D5 inhibits eosinophil infiltration in the brain of Angiostrongylus cantonensis-infected BALB/c mice

► We proved that 12D5 mAb can observably enhance the survival rate of infected mice and induce Symptoms of angiostrongyliasis. ► We proved 12D5 mAb can reduce the infiltration of eosinophils and severity of eosinophilic meningitis in BABL/c mice. ► We observed 12D5 mAb can increase the levels of eotaxin expression, decrease of IL-5, and keep same of IL-4 in the spleen.