Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni

► MT04 showed excellent fasciocidal properties in rats infected with juvenile and adult Fasciola hepatica. ► Microcalorimetry is a useful tool to study drug effects on F. hepatica in vitro. ► A good relationship with regard to compound sensitivity was observed between the F. hepatica Pacific Northwest wild strain harboured in rats and bovine slaughterhouse isolates. ► No relationship was observed between drug sensitivities on echinostomes and juvenile F. hepatica.