کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6129262 | 1222153 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bone marrow CD34+ progenitor cells may harbour HIV-DNA even in successfully treated patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Bone marrow CD34+ progenitor cells may harbour HIV-DNA even in successfully treated patients Bone marrow CD34+ progenitor cells may harbour HIV-DNA even in successfully treated patients](/preview/png/6129262.png)
چکیده انگلیسی
The issue about bone marrow hematopoietic progenitor cells harbouring HIV-DNA in infected patients is still under scrutiny. We studied nine HIV-infected individuals undergoing bone marrow aspiration for diagnostic purposes. In all patients, even in those receiving successful antiretroviral therapy for several years, HIV-DNA was detected in purified CD34+ lineage-bone marrow progenitor cells. This finding, although not conclusive due to the low number of patients examined, adds further evidence that current treatment strategies may be insufficient to resolve latent infection in bone marrow CD34+ hematopoietic progenitor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 21, Issue 3, March 2015, Pages 290.e5-290.e8
Journal: Clinical Microbiology and Infection - Volume 21, Issue 3, March 2015, Pages 290.e5-290.e8
نویسندگان
V. Bordoni, M. Bibas, I. Abbate, D. Viola, G. Rozera, C. Agrati, A. Rinaldi, A. Amendola, A. Ammassari, M.R. Capobianchi, F. Martini,