کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6129636 | 1222162 | 2015 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The mosaic genome structure and phylogeny of Shiga toxin-producing Escherichia coli O104:H4 is driven by short-term adaptation
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کلمات کلیدی
Shiga toxin-producing Escherichia coli - Escherichia coli تولید کننده سم شژیNext-generation sequencing - تعیین توالی نسل بعدیGenomic islands - جزایر ژنومیAntibiotic resistance - مقاومت به آنتی بیوتیکProphages - پروفاژSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیComparative genomics - ژنومیک تطبیقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Shiga toxin-producing Escherichia coli (STEC) O104:H4 emerged as an important pathogen when it caused a large outbreak in Germany in 2011. Little is known about the evolutionary history and genomic diversity of the bacterium. The current communication describes a comprehensive analysis of STEC O104:H4 genomes from the 2011 outbreak and other non-outbreak-related isolates. Outbreak-related isolates formed a tight cluster that shared a monophyletic relation with two non-outbreak clusters, suggesting that all three clusters originated from a common ancestor. Eight single nucleotide polymorphisms, seven of which were non-synonymous, distinguished outbreak from non-outbreak isolates. Lineage-specific markers indicated that recent partitions were driven by selective pressures associated with niche adaptation. Based on the results, an evolutionary model for STEC O104:H4 is proposed. Our analysis provides the evolutionary context at population level and describes the emergence of clones with novel properties, which is necessary for developing comprehensive approaches to early warning and control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 21, Issue 5, May 2015, Pages 468.e7-468.e18
Journal: Clinical Microbiology and Infection - Volume 21, Issue 5, May 2015, Pages 468.e7-468.e18
نویسندگان
K. Zhou, M. Ferdous, R.F. de Boer, A.M.D. Kooistra-Smid, H. Grundmann, A.W. Friedrich, J.W.A. Rossen,