کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6130672 | 1222191 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia](/preview/png/6130672.png)
چکیده انگلیسی
The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 19, Issue 10, October 2013, Pages E447-E450
Journal: Clinical Microbiology and Infection - Volume 19, Issue 10, October 2013, Pages E447-E450
نویسندگان
A. GradÃssimo Oliveira, C. Delgado, N. Verdasca, Ã. Pista,