کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6130893 1222198 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phenotyping of Staphylococcus aureus reveals a new virulent ST398 lineage
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Phenotyping of Staphylococcus aureus reveals a new virulent ST398 lineage
چکیده انگلیسی
Staphylococcus aureus sequence type (ST)398, which is commonly found as a colonization strain in pig farming, is emerging more frequently as the cause of human infections. In this study, we analysed ST398 of porcine and human origin at the genetic, protein and immunogenic levels. Although genetic analysis of the genes encoding the major virulence factors revealed the presence of the same genes in all strains studied, the results demonstrated spa type crossing alterations in adhesion abilities in addition to a strongly enhanced lysis activity directly linked to impaired clearance attributable to polymorphonuclear leukocytes (PMNs). This change in virulence pattern indicates high heterogenicity in the ST398 pool that is not based on a different genetic make-up, but probably on variations in the genetic regulation systems. These modifications, which are tightly connected to pathogenicity, cannot be detected by conventional diagnostic methods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 19, Issue 3, March 2013, Pages 279-285
نویسندگان
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