کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6131168 1222206 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of carbapenem resistance during therapy for non-typhoid Salmonella infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Development of carbapenem resistance during therapy for non-typhoid Salmonella infection
چکیده انگلیسی
Multidrug-resistant Salmonella infection is a global problem, and carbapenems may represent the last therapeutic choice. We report a case of infection caused by ceftriaxone-resistant and ciprofloxacin-resistant Salmonella enterica serotype Typhimurium. A blaCMY-2-containing Tn6092, located on a self-transferable IncI1 plasmid, was found in all isolates derived from the patient. During ertapenem treatment, the strain developed carbapenem resistance. Apart from the OmpD deficiency found in all isolates, the strain further developed OmpC deficiency through a single gene mutation, and became carbapenem-resistant. Salmonella appears to be very plastic in developing antimicrobial resistance. Care must be taken by physicians when treating multidrug-resistant Salmonella infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 18, Issue 4, April 2012, Pages E91-E94
نویسندگان
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