Posttranslational modifications and assembly of septin heteropolymers and higher-order structures

► There are no fungal septin residues that are universally modified and only a few pairs that are identically modified. ► Posttranslational modifications of septins appear to be evolutionarily recent. ► G domain posttranslational modifications cluster near the G interface, where they probably modulate heteropolymer formation. ► N-terminal and C-terminal modifications are scattered, where they probably modulate unique higher-order structures.