Chemosensory signaling controls motility and subcellular polarity in Myxococcus xanthus

► Dynamic localization of motility organelles in M. xanthus is regulated by Frz signaling. ► Cell polarity requires the Ras-like GTPase and GAP proteins MglA and MglB. ► Coordinated secretion of EPS and pilin is required for social motility. ► Recent studies reveal that gliding motility is powered by distributed motor complexes.