کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6132268 | 1222503 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Turning on the spotlight - using light to monitor and characterize bacterial effector secretion and translocation
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
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چکیده انگلیسی
Secretion and translocation of bacterial pathogen effectors into host cells via dedicated secretion machineries like type III secretion systems (T3SSs) or type IV secretion systems (T4SSs) is a key feature employed by pathogens to attack host cells. Innovative fluorescence and imaging approaches have blossomed during recent years, and became instrumental in revealing the dynamics of effector secretion and function in interfering with host cellular processes, particularly signaling events, gene expression regulation, membrane trafficking, and autophagy. Furthermore, imaging-based screening approaches have demonstrated the mode of action of several bacterial effectors upon host cellular translocation. The rapid technological advancement of imaging technologies indicates that these techniques will continue to be at the center of numerous future breakthroughs delineating the dynamic processes of bacterial effector actions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Microbiology - Volume 12, Issue 1, February 2009, Pages 24-30
Journal: Current Opinion in Microbiology - Volume 12, Issue 1, February 2009, Pages 24-30
نویسندگان
Soudeh Ehsani, Cristina D Rodrigues, Jost Enninga,