کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6132286 | 1222503 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Shigella type III secretion effectors: how, where, when, for what purposes?
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
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چکیده انگلیسی
Bacteria of Shigella spp., the causative agents of shigellosis in humans, possess a repertoire of â¼25-30 effectors injected into host cells by a type III secretion apparatus (T3SA). The T3SA activity is activated upon contact of bacteria with cells and controls expression of some effectors. Recent structural and functional studies suggest that two different sets of effectors are involved in inducing actin cytoskeleton reorganization to promote entry of bacteria into epithelial cells and in modulating cell signaling pathways to dampen innate immune responses induced upon infection, respectively. Schematically, effectors involved in entry are produced independently of the T3SA activity, whereas effectors involved in controlling the cell responses are produced upon activation of the T3SA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Microbiology - Volume 12, Issue 1, February 2009, Pages 110-116
Journal: Current Opinion in Microbiology - Volume 12, Issue 1, February 2009, Pages 110-116
نویسندگان
Claude Parsot,