Single cell genomics: an individual look at microbes

► Single cell genomics (SCG) analyzes DNA at the most fundamental level of biology. ► SCG uncovers metabolic potential of the uncultured microorganisms. ► In situ studies of microbial predation, infections and symbioses are enabled. ► SCG will improve our understanding of prokaryote diversity and diversification. ► Genomic bioprospecting of the microbial uncultured majority is enabled by SCG.