Systems biology of host-fungus interactions: turning complexity into simplicity

► Understanding the complexity of host-fungus interactions during commensalism. ► Genes mediating host colonization or fitness can evolve into infection-associated traits. ► Using bioinformatics to unravel functional genomics in dual-genome datasets. ► Modeling both fungal and host immune responses using network analysis tools. ► Databases and web-based resources for investigating host-pathogen interactions.